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Golimumab is a fully human anti-tumor necrosis factor-alpha (TNF-α) monoclonal antibody with clinical efficacy in the treatment of rheumatoid arthritis. The aim of the present meta-analysis was to evaluate the effect of golimumab on psoriasis and psoriatic arthritis (PsA). A systematic literature search was conducted in PubMed, EMBASE, and the Cochrane Central Register of Controlled Trials to identify relevant randomized controlled trials (RCTs). The effect of golimumab was compared with placebo or traditional systemic agents such as methotrexate (MTX), cyclosporin, fumaric acid esters, or TNF-α inhibitors with regard to the efficacy of clinical response, American College of Rheumatology (ACR) 20/50/70/90 response, and ACR20/50/70/90 with CDAI or SDAI (CDAI/SDAI) response or SDAI 0, SDAI 1/2, and SDAI 3/4. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated for the comparisons. Overall, 15 RCTs involving 1532 patients were identified. Pooled efficacy results of golimumab in psoriasis were as follows: ACR20/50/70/90 of clinical response: OR 1.32 (95% CI, 1.15-1.51), ACR20/50/70/90 (CDAI/SDAI): OR 1.60 (95% CI, 1.43-1.78) and SDAI 0/1/2/3/4: OR 1.72 (95% CI, 1.30-2.28). The therapeutic efficacy of golimumab in PsA was as follows: ACR20/50/70/90 of clinical response: OR 1.55 (95% CI, 1.32-1.82), ACR20/50/70/90 (CDAI/SDAI): OR 1.76 (95% CI, 1
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