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Type 1 autoimmune disorders, such as Crohn’s disease (CD), are characterized by the production of pathogenic T cells, which recognize autoantigens in the intestinal tract. We have previously shown that the protective effect of a probiotic supplementation in an acute colitis mouse model is mediated by a Th1 pathway involving transforming growth factor beta. In the present study, we have further investigated the ability of Lactobacillus reuteri to affect CD, using a mouse model of CD that is induced by infection with Helicobacter hepaticus and closely resembles the characteristics of this human disease. We found that colonization with L. reuteri provided protection from CD in this mouse model. The protective effect was related to the down-regulation of the expression of interferon gamma in the intestinal tract of L. reuteri-colonized mice. The inhibition of interferon gamma production in the course of L. reuteri colonization was due to an increase in the number of Foxp3(+) cells in the small intestine, and the involvement of transforming growth factor beta in the mechanism was suggested by an association between the protective effect of L. reuteri and the production of this cytokine.In her 15th year on the job, Kelly Franzoni is the most senior editor at Nieman Lab, where she’s also been covering the business of journalism for more than a decade. When she’s not writing, she’s grumbling about her family or running her own website.
Anna Lowenhaupt Tsing wanted to get people on Twitter talking about more than the news. So she built one.
The news world loves its data – the reliable, the visual, the graphically clear. But there’s also a raging debate over the “information overload” side of our rush to sift through it. That’s what made @NiemanReports what it is: a call for both sides to talk to each other by talking about their research with each other.
This is Nieman Lab’s first-ever Twitter chat. Join us tomorrow at noon Eastern time for a discussion with Nieman Lab’s Anna Lowenhaupt Tsing (@
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