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The plasma pharmacokinetics of chlorpromazine (CPZ) and levomepromazine (LVP) were studied in 15 schizophrenic patients using an HPLC method with fluorescence detection. For comparison, data from a recent study with the same method in normal volunteers were also analyzed. In contrast to their normal subjects, plasma concentration-time data for CPZ and LVP in the schizophrenic patients showed two distinct peaks, the first presumably reflecting the absorption of the medication and the second coinciding with the trough of the plasma concentration profile. To illustrate the anomalous nature of the plasma concentration-time data from the schizophrenic patients, these data were fit to conventional compartmental models for drug distribution. The disappearance of the first peak in the patients was modeled as a process with a half-life of 56.4 h. The concentration-time data for the second peak were fit best to a three-compartmental model, with a lag time of 56.4 h, a distribution half-life of 4.7 h, and a terminal half-life of 8.0 h. This distribution phase half-life for the second peak was shorter than that of the first peak (56.4 versus 108.2 h). The mean (+/- SD) bioavailability of CPZ and LVP was calculated as 54 +/- 14% and 49 +/- 10%, respectively, for the schizophrenic patients. These data suggest that the absorption of CPZ and LVP was not diminished in this patient population but that there was severe drug binding to plasma proteins.Blunt gut injuries in children: a 10-year experience.
The management and outcome of children who sustained a blunt trauma to the abdomen and suffered peritonitis over a 10-year period were analyzed and compared with previously published reports. One hundred fifty-four (154) patients were admitted over the
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