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Marvel’s Agents of SHIELD: Season 3 is now on ABC. Marvel’s Agents of SHIELD: Season 3 is now on ABC. See Keywords tab for how to make movie cards.Primary Prostate Cancer: The Case for Active Surveillance.
The implementation of regular prostate-specific antigen (PSA) screening has resulted in a large increase in the incidence of non-organ confined (NOC) and early stage prostate cancer. Debate continues over the optimal management of these cancers. In this review, we examine whether the clinical characteristics of these cancers supports a screening strategy with active surveillance (AS), a conservative strategy in which the detection and curative treatment of these cancers would be avoided, without any loss of life expectancy. Published data was identified through MEDLINE (1946-2012). Key search terms included primary prostate cancer, prostate-specific antigen, active surveillance, docetaxel and estramustine. The reduction in prostate cancer-specific mortality and biochemical relapse rates for NOC tumours after radical prostatectomy is well recognised, although patients with clinically significant tumours have higher rates of biochemical recurrence, local recurrence and higher progression of grade to Gleason 9 disease. The local control and low rates of progression and complications for these tumours appear to be greater with AS than after prostatectomy. Because most localised tumours are initially managed with AS, the potential to avoid unnecessary radical surgery in this group of patients appears to be an advantage. The use of ADT and/or minimally invasive surgery for AS is an area of interest for the management of NOC tumours.
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